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Antigenic Specificity | MSK1 (Ab-376) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MSK1 protein. Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and str |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from Human MSK1. |
Other Names | [MSPK1; RPS6KA5] |
Gene, Accession # | [MSK1], Gene ID: 9252, NCBI: NP_004746.2, UniProt: O75582 |
Catalog # | MBS9414131 |
Price | $200, $255 |
Order / More Info | MSK1 (Ab-376) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |