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Antigenic Specificity | Human Hace 1 |
Clone | [8D3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 0.1 mg |
Concentration | 0.1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Hace 1 (This antibody is specific for human HACE 1.). Anti-Human HACE 1 monoclonal antibody binds HACE 1 (HECT domain and ankyrin repeat containing), an E3 ubiquitin protein ligase 1 that has ubiquitin ligase activity. HACE 1 was found to be a tumor suppressor which is down-regulated in human Wilm's tumor. HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increases tumor incidence in a HACE 1-deficient background. Re-expression of HACE1 in human |
Immunogen | Immunization: Mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1. Presentation: Biotin and FITC conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS520564 |
Price | $285 |
Order / More Info | Human Hace 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |