Human Hace 1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman Hace 1
Clone[8D3]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatbiotin conjugate
Size0.1 mg
Concentration0.1 mg/ml
ApplicationsWestern Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin
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DescriptionSpecificity: Hace 1 (This antibody is specific for human HACE 1.). Anti-Human HACE 1 monoclonal antibody binds HACE 1 (HECT domain and ankyrin repeat containing), an E3 ubiquitin protein ligase 1 that has ubiquitin ligase activity. HACE 1 was found to be a tumor suppressor which is down-regulated in human Wilm's tumor. HACE1 is frequently downregulated in human tumors and maps to a region of chromosome 6q21 implicated in multiple human cancers. Genetic inactivation of HACE1 results in the development of spontaneous, late-onset cancer. A second hit from either environmental triggers or genetic heterozygosity of another tumor suppressor, p53, markedly increases tumor incidence in a HACE 1-deficient background. Re-expression of HACE1 in human
ImmunogenImmunization: Mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1. Presentation: Biotin and FITC conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
Other Namesn/a
Gene, Accession #n/a
Catalog #MBS520564
Price$285
Order / More InfoHuman Hace 1 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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