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Antigenic Specificity | FUBP1 |
Clone | [AT14F5] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, k |
Format | Protein A purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1 mg/ml |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | FUBP1 is a transcriptional regulator and fulfills an important function in the precise control of c-myc transcription. The c-Myc protein is a transcription factor which regulates the transcription of many different target genes that play a role in proliferation, cell cycle progression, differentiation, apoptosis and cell metabolism. Consequently, FUBP1 is also involved in the regulation of proliferation and differentiation, as confirmed by different experimental approaches. Knockdown of FUBP1 or expression of a dominant-negative FUBP1 (DNA-binding domain lacking effector activity) led to proliferation arrest in U2OS and Saos-2 osteosarcoma cells due to reduced c-myc expression. |
Immunogen | Immunogen: Recombinant human FUBP1 (279-448aa) purified from E Coli |
Other Names | [Far upstream element (FuSE) binding protein 1; FBP; FuBP], [FUBP1; FUBP1; FBP; FUBP; hDH V; FBP; FUSE-binding protein 1; hDH V] |
Gene, Accession # | [FUBP1], Gene ID: 8880, NCBI: NP_003893, UniProt: Q96AE4 |
Catalog # | MBS200377 |
Price | $240, $315 |
Order / More Info | FUBP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Duncan R., et al. (1994) Genes Dev. 8 (4): 465-480.; Liu J., et al. (2006) EMBO J. 25 (10): 2119-2130. |