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Antigenic Specificity | Human CD137L |
Clone | [ANC5D6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2ak |
Format | unconjugated |
Size | 0.1 mg |
Concentration | 1.0 mg/ml |
Applications | Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Information: Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells (1), and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8 effector T cells than for CD4 helper T cells (3). The interaction can also effect a reverse signal, inducing monocyte activation (2), or T cell inactivation and programmed death (4) through CD137L. Anti-CD137L antibody clone ANC5D6 binds to CD137L present on Raji and U-937 cells, and also binds to recombinant CD137L-muCD8 in EIA. This antibody does not block the interaction between CD137 and CD137L. |
Immunogen | Immunogen: Recombinant human CD137L |
Other Names | n/a |
Gene, Accession # | [CD137L] |
Catalog # | MBS666016 |
Price | $440 |
Order / More Info | Human CD137L Antibody from MYBIOSOURCE INC. |
Product Specific References | 1) M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227. 2) J. Langstein, et al, (1998) J Immunol 160: 2488-2494. 3) V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627. 4) H. Schwartz, et al, (1996) Blood 87: 2839. 5) G. Zhu, et al, (2001) J Immunol 167: 2671-6. |