Human CD137L Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHuman CD137L
Clone[ANC5D6]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2ak
Formatunconjugated
Size0.1 mg
Concentration1.0 mg/ml
ApplicationsFlow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
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DescriptionInformation: Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells (1), and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. This costimulus seems to be more effective for CD8 effector T cells than for CD4 helper T cells (3). The interaction can also effect a reverse signal, inducing monocyte activation (2), or T cell inactivation and programmed death (4) through CD137L. Anti-CD137L antibody clone ANC5D6 binds to CD137L present on Raji and U-937 cells, and also binds to recombinant CD137L-muCD8 in EIA. This antibody does not block the interaction between CD137 and CD137L.
ImmunogenImmunogen: Recombinant human CD137L
Other Namesn/a
Gene, Accession #[CD137L]
Catalog #MBS666016
Price$440
Order / More InfoHuman CD137L Antibody from MYBIOSOURCE INC.
Product Specific References1) M.R. Alderson, et al, (1994) Eur J Immunol 24: 2219-2227. 2) J. Langstein, et al, (1998) J Immunol 160: 2488-2494. 3) V.Y. Taraban, et al, (2002) Eur J. Immunol. 32: 3617-3627. 4) H. Schwartz, et al, (1996) Blood 87: 2839. 5) G. Zhu, et al, (2001) J Immunol 167: 2671-6.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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