LRRK2 (C-term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | LRRK2 (C-term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This LRRK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosp |
| Immunogen | n/a |
| Other Names | [Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2; PARK8] |
| Gene, Accession # | [LRRK2], Gene ID: 120892, NCBI: NP_940980.3, UniProt: Q5S007 |
| Catalog # | MBS9212935 |
| Price | $165, $370 |
| Order / More Info | LRRK2 (C-term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zimprich A.,et al.Neuron 44:601-607(2004). Scherer S.E.,et al.Nature 440:346-351(2006). Bechtel S.,et al.BMC Genomics 8:399-399(2007). Adams J.R.,et al.Brain 128:2777-2785(2005). Gloeckner C.J.,et al.Hum. Mol. Genet. 15:223-232(2006). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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