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Antigenic Specificity | PKC beta 2 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, |
Immunogen | Immunogen: A synthesized peptide derived from human PKC beta 2. Subcellular Localization: Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. |
Other Names | [Protein kinase C beta type; PKC-B; PKC-beta; 2.7.11.13; PRKCB; PKCB; PRKCB1], [PRKCB] |
Gene, Accession # | [PKC beta 2], Gene ID: 5579, NCBI: NP_002729.2, UniProt: P05771 |
Catalog # | MBS179772 |
Price | $160, $340, $340 |
Order / More Info | PKC beta 2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |