Edit |   |
---|---|
Antigenic Specificity | ARHGEF7 (C-Term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse; predicted reactivity: mouse |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ARHGEF7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 654-688 amino acids from human ARHGEF7. Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
Immunogen | n/a |
Other Names | [Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85; ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB] |
Gene, Accession # | [ARHGEF7], Gene ID: 8874, NCBI: NP_001106983.1, UniProt: Q14155 |
Catalog # | MBS9217308 |
Price | $165, $370 |
Order / More Info | ARHGEF7 (C-Term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Nagase T.,et al.DNA Res. 2:167-174 (1995). Bagrodia S.,et al.J. Biol. Chem. 273:23633-23636 (1998). Bechtel S.,et al.BMC Genomics 8:399-399 (2007). Dunham A.,et al.Nature 428:522-528 (2004). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. |