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Antigenic Specificity | p53 Tumor Suppressor Protein |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, monkey, dog, mouse, rat, hamster |
Isotype | n/a |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. TP53/3156R binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, TP53/3156R blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is da |
Immunogen | Immunogen: SV40-transformed Mouse B4 cells |
Other Names | [Antigen NY-CO-13; BCC7; Cellular Tumor Antigen p53; LFS1; TP53; Transformation Related Protein 53 (TRP53)] |
Gene, Accession # | [TP53], Gene ID: 7157, NCBI: NP_000537.3, UniProt: P04637 |
Catalog # | MBS4381307 |
Price | $190, $340, $340 |
Order / More Info | p53 Tumor Suppressor Protein Antibody from MYBIOSOURCE INC. |
Product Specific References | Gurney EG et. al. Journal of Virology, 1980, 34(3):752-63. |