Calreticulin Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCalreticulin
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat, bovine, dog, chicken, guinea pig, monkey, porcine, hamster, rabbit, sheep
Isotypen/a
FormatPeptide Affinity purified
Size0.05 mL
Concentration1 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
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DescriptionDetects ~63kDa. Calreticulin is a multifunctional, highly conserved Ca2+-binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT's three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity (1,3). Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be involved in calcium storage and regulati
ImmunogenImmunogen: Human calreticulin synthetic peptide with a cysteine residue added and the peptide conjugated to KLH Immunogen Species: Human
Other Names[Rabbit Human Calreticulin; CALR; Calregulin; cC1qR; CRP55; ERp60; HSCBP; RO; SSA; grp60]
Gene, Accession #Gene ID: 811, NCBI: NP_004334.1, UniProt: P27797
Catalog #MBS8002001
Price$215
Order / More InfoCalreticulin Antibody from MYBIOSOURCE INC.
Product Specific References1. Johnson S., et al. (2001) Trends Cell Biol 11: 122-129. 2. Smith M.J., et al. (1989) EMBO J. 8: 3581-3586. 3. Ellgaard L., et al. (2001) Curr Opin Cell Biol. 13: 431-437. 4. Krause K.H., and Michalak M. (1997) Cell. 88: 439-443. 5. Nash P.D., et al. (1994) Mol Cell Biochem. 135: 71-78. 6. Heal R., and McGivan J. (1998) Biochem J. 329: 389-394. 7. Lucero H.A., et al. (1998) J Biol Chem. 273: 9857-9863. 8. Tanaka S., et al. (2000) J Biol Chem. 275: 10388-10393. 9. Yoon G.S., et al. (2000) Cancer Res. 60: 1117-1120. 10. Antoniou A.N., et al. (2002) Immunology 106: 182-189. 11. Wada I., et al. (1997) EMBO J. 16: 5420-5432. 12. Laguerre D.B., et al. (1998) J Vir. 72: 4940-4949.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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