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Antigenic Specificity | Calreticulin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, bovine, dog, chicken, guinea pig, monkey, porcine, hamster, rabbit, sheep |
Isotype | n/a |
Format | Peptide Affinity purified |
Size | 0.05 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~63kDa. Calreticulin is a multifunctional, highly conserved Ca2+-binding protein that is localized to the endoplasmic reticulum (ER), but has also been detected in the nucleus and nuclear envelop. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus (1-3). CRT's three domains include a 180 residue N-terminal domain, a proline-rich P-domain (residues 189-288) that binds Ca2+ with high affinity and shares homology with calnexin (CNX) and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity (1,3). Recent studies suggest that this soluble ER protein has a multifunctional role. It appears to be involved in calcium storage and regulati |
Immunogen | Immunogen: Human calreticulin synthetic peptide with a cysteine residue added and the peptide conjugated to KLH Immunogen Species: Human |
Other Names | [Rabbit Human Calreticulin; CALR; Calregulin; cC1qR; CRP55; ERp60; HSCBP; RO; SSA; grp60] |
Gene, Accession # | Gene ID: 811, NCBI: NP_004334.1, UniProt: P27797 |
Catalog # | MBS8002001 |
Price | $215 |
Order / More Info | Calreticulin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Johnson S., et al. (2001) Trends Cell Biol 11: 122-129. 2. Smith M.J., et al. (1989) EMBO J. 8: 3581-3586. 3. Ellgaard L., et al. (2001) Curr Opin Cell Biol. 13: 431-437. 4. Krause K.H., and Michalak M. (1997) Cell. 88: 439-443. 5. Nash P.D., et al. (1994) Mol Cell Biochem. 135: 71-78. 6. Heal R., and McGivan J. (1998) Biochem J. 329: 389-394. 7. Lucero H.A., et al. (1998) J Biol Chem. 273: 9857-9863. 8. Tanaka S., et al. (2000) J Biol Chem. 275: 10388-10393. 9. Yoon G.S., et al. (2000) Cancer Res. 60: 1117-1120. 10. Antoniou A.N., et al. (2002) Immunology 106: 182-189. 11. Wada I., et al. (1997) EMBO J. 16: 5420-5432. 12. Laguerre D.B., et al. (1998) J Vir. 72: 4940-4949. |