MARCO, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MARCO, Human |
| Clone | PLK-1 |
| Host Species | Mouse |
| Reactive Species | reactivity: human. cross reactivity: bovine |
| Isotype | IgG3 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoflurescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody PLK-1 recognizes the macrophage receptor with collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of |
| Immunogen | Immunogen: Human alveolar macrophages (recognizes domain V between residues 420 and 431) |
| Other Names | n/a |
| Gene, Accession # | [MARCO] |
| Catalog # | MBS584406 |
| Price | $665 |
| Order / More Info | MARCO, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Palecanda, A et al; Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. Curr Mol Med 2001, 1: 589 2. Bunn, H et al; MARCO expression on pediatric alveolar macrophages. Cytometry 2004, 60B: 54 3. Arredouani, M, et al; MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. J Immunol 2005, 175: 6058 4. Martens, J-H et al; Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J Pathol 2006, 208: 574 5. Hamilton, R et al; MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 2006, 281: 34218 6. Bowdish, D et al; MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PloS Pathog 2009, 5: e1000474 |
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MYBIOSOURCE INC.
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