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Antigenic Specificity | GFR alpha 3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | DEAE purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a peptide corresponding to amino acids from 347 to 360 of murine GFR alpha 3. |
Other Names | [GFRa-3, GDNFRg, GDNFRgamma] |
Gene, Accession # | [GFR alpha 3], NCBI: ab008833 |
Catalog # | MBS9409885 |
Price | $320 |
Order / More Info | GFR alpha 3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |