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Antigenic Specificity | ZBTB33 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 523-672 of human ZBTB33 (NP 006768.1). |
Other Names | [ZNF348; ZNF-kaiso] |
Gene, Accession # | [ZBTB33], Gene ID: 10009, NCBI: NP_001171671.1, UniProt: Q86T24 |
Catalog # | MBS8548761 |
Price | $280 |
Order / More Info | ZBTB33 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |