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Antigenic Specificity | HMGB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | High mobility group protein B1 (HMGB1) belongs to a family of highly conserved proteins that contain HMG box domains (1, 2). All three family members (HMGB1, HMGB2, and HMGB3) contain two HMG box domains and a C-terminal acidic domain. HMGB1 is a widely expressed and highly abundant protein (2). HMGB2 is widely expressed during embryonic development, but is restricted to lymphoid organs and testis in adult animals (3). HMGB3 is only expressed during embryogenesis (4). While expression varies, the biochemical properties of the different family members may be indistinguishable. The HMG box domains facilitate the binding of HMGB proteins to the minor groove of DNA, which results in local bending of the DNA double helix (1, 2). HMGB proteins ar |
Immunogen | Immunogen: Recombinant protein of human HMGB1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [DKFZp686A04236; HMG1; HMG3; SBP-1] |
Gene, Accession # | [HMGB1], Gene ID: 3146, NCBI: NP_001300821.1, UniProt: P09429 |
Catalog # | MBS8500552 |
Price | $310 |
Order / More Info | HMGB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Thomas, J.O. and Travers, A.A. (2001) Trends Biochem Sci 26, 167-74. 2. Muller, S. et al. (2004) J Intern Med 255, 332-43. 3. Ronfani, L. et al. (2001) Development 128, 1265-73. 4. Vaccari, T. et al. (1998) Genomics 49, 247-52. 5. Campana, L. et al. (2008) Curr Opin Immunol 20, 518-23. 6. Klune, J.R. et al. (2008) Mol Med 14, 476-84. |