HMGB1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHMGB1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionHigh mobility group protein B1 (HMGB1) belongs to a family of highly conserved proteins that contain HMG box domains (1, 2). All three family members (HMGB1, HMGB2, and HMGB3) contain two HMG box domains and a C-terminal acidic domain. HMGB1 is a widely expressed and highly abundant protein (2). HMGB2 is widely expressed during embryonic development, but is restricted to lymphoid organs and testis in adult animals (3). HMGB3 is only expressed during embryogenesis (4). While expression varies, the biochemical properties of the different family members may be indistinguishable. The HMG box domains facilitate the binding of HMGB proteins to the minor groove of DNA, which results in local bending of the DNA double helix (1, 2). HMGB proteins ar
ImmunogenImmunogen: Recombinant protein of human HMGB1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[DKFZp686A04236; HMG1; HMG3; SBP-1]
Gene, Accession #[HMGB1], Gene ID: 3146, NCBI: NP_001300821.1, UniProt: P09429
Catalog #MBS8500552
Price$310
Order / More InfoHMGB1 Antibody from MYBIOSOURCE INC.
Product Specific References1. Thomas, J.O. and Travers, A.A. (2001) Trends Biochem Sci 26, 167-74. 2. Muller, S. et al. (2004) J Intern Med 255, 332-43. 3. Ronfani, L. et al. (2001) Development 128, 1265-73. 4. Vaccari, T. et al. (1998) Genomics 49, 247-52. 5. Campana, L. et al. (2008) Curr Opin Immunol 20, 518-23. 6. Klune, J.R. et al. (2008) Mol Med 14, 476-84.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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