CENP-A Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CENP-A |
| Clone | [5A7-2E11] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | APC-Cy7 conjugate |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects ~18 kDa. Recognizes Human CENP-A. A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase |
| Immunogen | Immunogen: Synthetic peptide corresponding to a portion of human CENP-A |
| Other Names | [Mouse Human CENP-A IgG1; CENP-A : APC/Cy7; CENP A; cenpa; Centromere auto antigen A; Histone H3 like centromeric protein A] |
| Gene, Accession # | [CENP-A], Gene ID: 1058, NCBI: NP_001035891.1, UniProt: P49450 |
| Catalog # | MBS8002584 |
| Price | $495 |
| Order / More Info | CENP-A Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Rieder C.L., et al. (1998) Trends Cell Biol. 8: 310-318. 2. Choo K.H. (2000) Trends Cell Biol. 10: 182-188. 3. Muro Y., et al. (2000) Clin. Exp. Immunol. 120: 218-223. 4. Howman E.V., et al. (2000) Proc. Natl. Acad. Sci. USA 97: 1148-1153. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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