COBRA1/NELFB Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | COBRA1/NELFB |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Direct ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: No cross reactivity with other proteins. Description: Rabbit IgG polyclonal antibody for COBRA1 detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.Background: Cofactor of BRCA1, also known as COBRA1, is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2), either NELF-C or NELF-D (TH1L), and NELF-E (RDBP). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1) and SPT5 (SUPT5H), to cause transcriptional pausing of RNA polymerase II. COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait. |
| Immunogen | Immunogen: E Coli-derived human COBRA1 recombinant protein (Position: M1-E252). |
| Other Names | [Negative elongation factor B; NELF-B; Cofactor of BRCA1; NELFB; COBRA1; KIAA1182; Negative elongation factor complex member B] |
| Gene, Accession # | [COBRA1], Gene ID: 25920, NCBI: NP_056271.3, UniProt: Q8WX92 |
| Catalog # | MBS1751522 |
| Price | $280 |
| Order / More Info | COBRA1/NELFB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (2003). Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex. Molecular and Cellular Biology. 23 (6): 1863-1873. 2. Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R (2001). BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. The Journal of Cell Biology. 155 (6): 911-922. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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