DAB2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DAB2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DAB2 antibody detects endogenous levels of total DAB2. Function: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4, 5-bisphosphate (PtdIns(4, 5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins s |
| Immunogen | Immunogen: A synthesized peptide derived from human DAB2 Subcellular Location: Cytoplasmic Vesicle; Clathrin Coated Vesicle; Clathrin Coated Vesicle Membrane. Cell Membrane; Coated Pit; Clathrin Coated Pit. Note: Colocalizes with large insert containing isoforms of MYO6 at clathrin coated pits/vesicles. Tissue Specificity: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, ma |
| Other Names | [DAB 2; Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila); DAB2; Differentially expressed in ovarian cancer 2; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila); Disabled homolog 2 mitogen responsive phosphoprotein; Disabled, Drosophila, homolog of, 2; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein] |
| Gene, Accession # | [DAB2], Gene ID: 1601, NCBI: NP_001231800.1, UniProt: P98082 |
| Catalog # | MBS9608360 |
| Price | $240, $280 |
| Order / More Info | DAB2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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