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Antigenic Specificity | CD4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300-400 of human CD4 (NP 000607.1). |
Other Names | [CD4mut] |
Gene, Accession # | [CD4], Gene ID: 920, NCBI: NP_000607.1, UniProt: P01730 |
Catalog # | MBS8544439 |
Price | $280 |
Order / More Info | CD4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |