Edit |   |
---|---|
Antigenic Specificity | SOD1 (EDI) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, porcine |
Isotype | n/a |
Format | APC-Cy7 conjugate |
Size | 0.1 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a conformation specific epitope where the dimer interface is exposed. Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (2). It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms (3). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (2). Misfolding of SOD1 has been implicated in Amyotrophic lat |
Immunogen | Immunogen: N-terminal region of SOD1, exposed dimer interface (EDI) |
Other Names | [Rabbit Human SOD1 (EDI); SEDI; SOD1 EDI; Superoxide dismutase 1; SOD; SOD1 exposed dimer interface] |
Gene, Accession # | [SOD1], Gene ID: 6647, NCBI: P00441.2, UniProt: P00441 |
Catalog # | MBS8004421 |
Price | $495 |
Order / More Info | SOD1 (EDI) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180. 2. Furukawa Y., and O'Halloran T. (2006) Antioxid Redox Signal. 8(5-6):847-67. 3. Gao B., et al. (2003) Am J Physiol Lung Cell Mol Physiol. 284:L917-L925. 4. Hassan H.M. (1988) Free Radical Biol. Med. 5:377-385. 5. Kerman A., et al. (2010) Acta Neuropathol. 119:335-344. |