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Antigenic Specificity | DCC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total DCC protein. Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.Hedrick L., Genes Dev. 8:1174-1183(1994).Cho K.R., Genomics 19:525-531(1994).Sjoeblom T., Science 314:268-274(2006). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human DCC. |
Other Names | [colorectal cancer suppressor; deleted in colorectal carcinoma; netrin receptor DCC; tumor suppressor protein DCC] |
Gene, Accession # | [DCC], Gene ID: 1630, NCBI: NP_005206.2, UniProt: P43146 |
Catalog # | MBS9405453 |
Price | $200, $255 |
Order / More Info | DCC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |