EHMT2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | EHMT2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | G9a, also known as Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identified in Drosophila Su[var]3-9, Enhancer of zeste, and Trithorax proteins (1). Recombinant G9a can mono-, di-and tri-methylate histone H3 on Lys9 and Lys27 in vitro (1, 2). However, in vivo G9a forms a complex with GLP, a G9a-related histone methyltransferase, and together these proteins function as the major euchromatic histone H3 Lys9 mono-and di-methyltransferases, creating transcriptionally repressive marks that facilitate gene silencing (3, 4). G9a methylates itself on Lys165, a modification that regulates the association of HP1 |
| Immunogen | Immunogen: A synthetic peptide of human EHMT2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [BAT8; C6orf30; DKFZp686H08213; FLJ35547; G9A; KMT1C; NG36; NG36/G9a] |
| Gene, Accession # | [EHMT2], Gene ID: 10919, NCBI: NP_001276342.1, UniProt: Q96KQ7 |
| Catalog # | MBS8504063 |
| Price | $310 |
| Order / More Info | EHMT2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Tachibana, M. et al. (2001) J Biol Chem 276, 25309-17. 2. Patnaik, D. et al. (2004) J Biol Chem 279, 53248-58. 3. Tachibana, M. et al. (2002) Genes Dev 16, 1779-91. 4. Tachibana, M. et al. (2005) Genes Dev 19, 815-26. 5. Sampath, S.C. et al. (2007) Mol Cell 27, 596-608. 6. Ueda, J. et al. (2006) J Biol Chem 281, 20120-8. 7. Ogawa, H. et al. (2002) Science 296, 1132-6. 8. Shi, Y. et al. (2003) Nature 422, 735-8. 9. Nishio, H. and Walsh, M.J. (2004) Proc Natl Acad Sci USA 101, 11257-62. 10. Esteve, P.O. et al. (2006) Genes Dev 20, 3089-103. 11. Tachibana, M. et al. (2007) EMBO J 26, 3346-59. 12. Kondo, Y. et al. (2007) Hepatol Res 37, 974-83. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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