ALS2CR2 (C-term L289), 274-303 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | ALS2CR2 (C-term L289), 274-303 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the C-terminal region of human ALS2CR2. ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent o |
| Immunogen | n/a |
| Other Names | [STE20-related kinase adapter protein beta; STRAD beta; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2; STRADB; ALS2CR2; ILPIP] |
| Gene, Accession # | [STRADB], Gene ID: 55437, NCBI: NP_001193793.1, UniProt: Q9C0K7 |
| Catalog # | MBS9209772 |
| Price | $165, $370 |
| Order / More Info | ALS2CR2 (C-term L289), 274-303 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003). Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002). Hadano, S., et al., Genomics 71(2):200-213 (2001). |
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MYBIOSOURCE INC.
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