SIRT1 (C19) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SIRT1 (C19) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB), CHIP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human SIRT1. The Sir2 protein in yeast is known to function in transcriptional silencing processes through the deacetylation of histones H3 and H4 (1). The more recently described human homologue of Sir2, known as SIRT1, has been found to associate with the tumor suppressor protein p53 (1-3). SIRT1 binds and deacetylates p53 with specificity for its C-terminal Lys382 residue in response to the upregulation of promyelocytic leukemia protein (PML) nuclear bodies or oncogenic Ras (2&3). The deacetylation of p53 SIRT1 has been shown to negatively regulate p53-mediated transcription, preventing cellular senescence and apoptosis induced by DNA damage and stress (1-3). |
| Immunogen | Immunogen: Synthetic peptide mapping to the carboxy terminal domain of human SIRT1. |
| Other Names | [SIRT1 protein; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent deacetylase sirtuin-1; SIR2-like protein 1; SIR2alpha; regulatory protein SIR2 homolog 1; sir2-like 1; sirtuin type 1; sirtuin 1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2], [SIRT1; SIRT1; SIR2; hSIR2; SIR2L1; SIR2L1; hSIRT1; hSIR2; 75SirT1] |
| Gene, Accession # | [SIRT1], Gene ID: 23411, NCBI: AAH12499.1, UniProt: Q96EB6 |
| Catalog # | MBS440072 |
| Price | $240 |
| Order / More Info | SIRT1 (C19) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.) Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB. 2006. Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation. PLoS Genet. Mar;2(3):e40. Epub 2006 Mar 31. 2.) Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. 2007. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet. Feb;39(2):237-42.1. Smith J. 2002. Human Sir2 and the 'silencing' of p53 activity. Trends Cell Biol. 12(9):404-406.2. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. 2001. HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107(2):149-159.3. Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T. 2002. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21(10):2383-2396. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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