PLCG2 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PLCG2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) (1). At least four families of PLCs have been identified: PLCbeta, PLC gamma, PLCdelta and PLC epsilon. The PLCbeta subfamily includes four members, PLCbeta1-4. All four members of the subfamily are activated by alpha-or beta-gamma-subunits of the heterotrimeric G-proteins (2, 3).Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA |
| Immunogen | Immunogen: Recombinant protein of human PLCG2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [PLCG2; APLAID; FCAS3] |
| Gene, Accession # | [PLCG2], Gene ID: 5336, NCBI: NP_002652.2, UniProt: P16885 |
| Catalog # | MBS8503350 |
| Price | $310 |
| Order / More Info | PLCG2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Singer, W. D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. 2. Smrcka, A. V. et al. (1991) Science 251, 804-807. 3. Taylor, S. J. et al. (1991) Nature 350, 516-518. 4. Yue, C. et al. (1998) J. Biol. Chem. 273, 18023-18027. 5. Yue, C. et al. (2000) J. Biol. Chem. 275, 30220-30225. 6. Margolis, B. et al. (1989) Cell 57, 1101-1107. 7. Kim, H. K. et al. (1991) Cell 65, 435-441. 8. Wang, Z. et al. (1998) Mol. Cell. Biol. 18, 590-597. 9. Watanabe, D. et al. (2001) J. Biol. Chem. 276, 38595-38601. 10. Ozdener, F. et al. (2002) Mol. Pharmacol. 62, 672-679. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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