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Antigenic Specificity | RRM1 (N-term), 71-100 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.38 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1. This gene encodes one of two non-identical subunits thatconstitute ribonucleoside-diphosphate reductase, an enzymeessential for the production of deoxyribonucleotides prior to DNAsynthesis in S phase of dividing cells. It is one of several geneslocated in the imprinted gene domain of 11p15.5, an importanttumor-suppressor gene region. Alterations in this region have beenassociated with the Beckwith-Wiedemann syndrome, Wilms tumor,rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, andbreast cancer. This gene may play a role in malignancie |
Immunogen | n/a |
Other Names | [Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; RRM1; RR1] |
Gene, Accession # | [RRM1], Gene ID: 6240, NCBI: NP_001024.1, UniProt: P23921 |
Catalog # | MBS9211875 |
Price | $165, $370 |
Order / More Info | RRM1 (N-term), 71-100 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) Vinolas, N., et al. Lung Cancer (2010) In press : Niida, H., et al. Genes Dev. 24(4):333-338(2010) Dong, S., et al. J Hematol Oncol 3, 10 (2010) : |