Edit |   |
---|---|
Antigenic Specificity | MAP4K4 |
Clone | [4H9E7] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Immunogen | Immunogen: Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli. |
Other Names | [HGK; NIK] |
Gene, Accession # | [MAP4K4], Gene ID: 9448, NCBI: NP_001229488.1, UniProt: O95819 |
Catalog # | MBS8538439 |
Price | $280 |
Order / More Info | MAP4K4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |