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Antigenic Specificity | Glypican-3 |
Clone | [IHC405] |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL (Concentrate), 7 mL (Prediluted), 1 mL (Concentrate) |
Concentration | n/a |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Glypican-3 (GPC3) is a GPI-archored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumor marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms' tumor. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, which is higher than cirrhotic liver or liver with focal lesions including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumors of certain subtypes, such as yolk sac tumors and choriocarcinoma, and in embryonal tumors. |
Immunogen | n/a |
Other Names | [Glypican-3, partial; Glypican-3; Glypican-3], [GPC3] |
Gene, Accession # | NCBI: ETE59825.1 |
Catalog # | MBS344030 |
Price | $245, $435, $735 |
Order / More Info | Glypican-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Capurro M, et al. Gastroenterology. 2003; 125:89-97.2. Coston WMP, et al. Am J Surg Pathol. 2008; 32:433-44.3. Kandil D, et al. Cancer. 2007; 111:316-22.4. Zynger DL, et al. Hum Pathol. 2008; 39:224-30.5. Kandil DH, et al. Adv Anat Pathol. 2009; 16:125-9.6. Zynger DL, et al. Am J Surg Pathol. 2006; 30:1570-5. |