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Antigenic Specificity | UIMC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref. 37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 449-719 of human UIMC1 (NP 057374.3). |
Other Names | [RAP80; X2HRIP110] |
Gene, Accession # | [UIMC1], Gene ID: 51720, NCBI: Q96RL1.2, UniProt: Q96RL1 |
Catalog # | MBS8549481 |
Price | $280 |
Order / More Info | UIMC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |