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Antigenic Specificity | Glutamic acid decarboxylase |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, Cat |
Isotype | n/a |
Format | Protein A purified |
Size | 0.025 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human, mouse, rat and cat GAD. Detects two isoforms of ~65kDa and ~67 kDa by Western Blot. Glutamic acid decarboxylase (GAD; E.C. 4.1.1.15) is the enzyme responsible for the conversion of glutamic acid to gamma-aminobutyric acid (GABA) - the major inhibitory transmitter in higher brain regions. Two molecular forms of GAD (GAD65 and GAD67) are known from rat, cat, pig and man, and both forms are expressed in the CNS and in pancreatic islet endocrine cells. A recent Western blotting study has identified that the isoforms are regionally distributed in the brains of rats and mice. In rat pancreas, GAD65 and GAD67 appear to be differentially localised, GAD65 primarily in insulin-containing ( beta ) cells and GAD67 in glucagon-containi |
Immunogen | Immunogen: Synthetic peptide corresponding to aa 572-585 (D572FLIEEIERLGQDL585) of rat glutamate decarboxylase (GAD65). This sequence is conserved in rat GAD67 and in human GAD-2. |
Other Names | [glutamic acid decarboxylase, partial; Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform], [GAD2; GAD65; GAD-65] |
Gene, Accession # | [GAD], NCBI: AAA52513.1 |
Catalog # | MBS565359 |
Price | $200, $460 |
Order / More Info | Glutamic acid decarboxylase Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |