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Antigenic Specificity | RIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: RIP (Receptor Interacting Protein) is a 74 kDa Ser/Thr kinase which interacts with CD95 (Fas/Apo1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID, and TRAF2. RIP contains an N-terminal region with homology to protein kinase, an intermediate domain capable of association with MAPKKK and a C-terminal region containing an intracellular death domain motif. RIP activates both p38 MAP kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 645 of human RIP |
Other Names | [RIPK1; FLJ39204; Rinp; RIPK1; Receptor interacting protein], [RIPK1; RIPK1; RIP; RIP1; RIP; RIP1; RIP-1] |
Gene, Accession # | [RIP], Gene ID: 8737, NCBI: NP_003795.2, UniProt: Q13546 |
Catalog # | MBS841093 |
Price | $150, $300 |
Order / More Info | RIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |