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Antigenic Specificity | Mouse Emilin-1 |
Clone | [IgG2a/kappa, C11A8] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | n/a |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) - Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Emilin-1 is an extracellular matrix glycoprotein localized at sites where elastin and microfibrils are in proximity. It may be responsible for anchoring smooth muscle cells to elastic fibers. It has cell adhesive capacity. Emilin-1 may have a role in the regulation of blood vessel assembly since it inhibits TGFB signaling by binding specifically to the pro-TGFB precursor and preventing its maturation by furin convertases in the extracellular space. TGFB proteins are the main regulators of blood vessel development and maintenance. |
Immunogen | Immunogen: recombinant mouse Emilin-1. Preparation: Monoclonals were produced with the help of Wistar rat using recombinant murine Emilin-2 as immunizing antigen |
Other Names | [mouse Emilin-1 (#C11A8); Elastin micofibril interface-located protein 1], [Emilin1; Emilin1; gp115; AW229038; BB105748; EMILIN-1; 5830419M17Rik; Elastin microfibril interfacer 1] |
Gene, Accession # | Gene ID: 100952, NCBI: NP_598679.1, UniProt: Q99K41 |
Catalog # | MBS690964 |
Price | $365 |
Order / More Info | Mouse Emilin-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Colombatti A et al, J Cell Biol 100:18, 1985. 3. Doliana R et al, J Biol Chem 274:16773, 1999. 4. Zanetti M et al, Mol Cell Biol 24:638, 2004 5. Zacchigna L et al, Cell 124:929, 2006 6. Danussi C et al, Mol Cell Biol 28:4026, 2008. 7. Danussi C et al, J Cell Biol, in press |