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Antigenic Specificity | STEP / PTPN5 (N-Term), 168-198 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5. STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting |
Immunogen | n/a |
Other Names | [Tyrosine-protein phosphatase non-receptor type 5; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; STEP; PTPN5] |
Gene, Accession # | [PTPN5], Gene ID: 84867, NCBI: NP_001035059.1, UniProt: P54829 |
Catalog # | MBS9204706 |
Price | $165, $370 |
Order / More Info | STEP / PTPN5 (N-Term), 168-198 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ota, T., et al., Nat. Genet. 36(1):40-45 (2004). Li, X., et al., Genomics 28(3):442-449 (1995). |