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Antigenic Specificity | Human MHC Class I |
Clone | [3F10] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | purified |
Size | 0.1 mg |
Concentration | 1.0 mg/ml |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Information: Human MHC Class I (HLA-A, B & C) molecules are expressed on nearly all nucleated cells. MHC Class I molecules consist of heterodimers of a highly polymorphic transmembrane alpha chain and an invariant beta chain. MHC Class I molecules bind to endogenously synthesized peptides of about 8-10 amino acids which are presented to CD8 T cells. Recent evidence now indicates exogenously derived peptides are also presented by MHC Class I molecules. Antibody 3F10 recognizes a monomorphic Class I epitope on the a chain. |
Immunogen | Immunogen: Human HSB-2 T cell line |
Other Names | n/a |
Gene, Accession # | NCBI: AAB08079.1 |
Catalog # | MBS666184 |
Price | $270 |
Order / More Info | Human MHC Class I Antibody from MYBIOSOURCE INC. |
Product Specific References | G.S. Eisenbarth, et al, (1980) J Immunol 124: 1237-1244. P.J. Bjorkman & P. Parham, (1990) Annu Rev Biochem 59: 253-288. L.D. Barber & P. Parham, (1994) J Exp Med 180: 1191-1194. K.L. Rock, (1996) Immunol Today 17: 131-137. |