FASN (Center), 942-973 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | FASN (Center), 942-973 |
| Clone | [497CT15.2.5] |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | IgM |
| Format | unconjugated |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Immunofluorescence (IF), ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This FASN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 942-973 amino acids from the Central region of human FASN. The enzyme encoded by this gene is a multifunctionalprotein. Its main function is to catalyze the synthesis ofpalmitate from acetyl-CoA and malonyl-CoA, in the presence ofNADPH, into long-chain saturated fatty acids. In some cancer celllines, this protein has been found to be fused with estrogenreceptor-alpha (ER-alpha), in which the N-terminus of FAS is fusedin-frame with the C-terminus of ER-alpha. |
| Immunogen | n/a |
| Other Names | [Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FASN; FAS] |
| Gene, Accession # | [FASN], Gene ID: 2194, NCBI: NP_004095.4, UniProt: P49327 |
| Catalog # | MBS9200116 |
| Price | $165, $370 |
| Order / More Info | FASN (Center), 942-973 Antibody from MYBIOSOURCE INC. |
| Product Specific References | References for protein: 1.Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) 2.Nguyen, P.L., et al. J. Clin. Oncol. 28(25):3958-3964(2010) 3.Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) 4.Tischler, V., et al. Histopathology 56(6):811-815(2010) 5.Dorn, C., et al. Int J Clin Exp Pathol 3(5):505-514(2010) References for HepG2 cell line: 1. Knowles BB, et al. (1980). Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209: 497-499.[ PubMed: 6248960]. 2. Darlington GJ, et al. (1987). Growth and hepatospecific gene expression of human hepatoma cells in a defined medium. In Vitro Cell. Dev. Biol. 23: 349-354.[PubMed: 3034851]. 3. Ihrke, G; Neufeld, EB; Meads, T; Shanks, MR; Cassio, D; Laurent, M; Schroer, TA; Pagano, RE et al. (1993). WIF-B cells: an in vitro model for studies of hepatocyte polarity. Journal of Cell Biology 123 (6): 1761-1775. [PubMed:7506266]. 4. Mersch-Sundermann, V.; Knasmuller, S.; Wu, X. J.; Darroudi, F.; Kassie, F. (2004). Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 198 (1-3): 329-340. [PubMed:15138059]. |
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MYBIOSOURCE INC.
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