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Antigenic Specificity | RNF144B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 2.4mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p |
Immunogen | Immunogen: Recombinant protein of human RNF144B Calculated Molecular Weight: 34kDa |
Other Names | [PIR2; IBRDC2; p53RFP; bA528A10.3] |
Gene, Accession # | [RNF144B], NCBI: AIC61598.1 |
Catalog # | MBS2528336 |
Price | $110, $150, $225 |
Order / More Info | RNF144B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |