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Antigenic Specificity | RNF8 (Ab-198) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total RNF8 protein. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP t |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.196~200 (A-S-T-P-S) derived from Human RNF8. |
Other Names | [KIAA0646] |
Gene, Accession # | [RNF8], Gene ID: 9025, NCBI: NP_003949.1, UniProt: O76064 |
Catalog # | MBS9409432 |
Price | $200, $255 |
Order / More Info | RNF8 (Ab-198) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |