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Antigenic Specificity | AKT1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The serine-threonine protein kinase AKT1 is catalytically inactive inserum-starved primary and immortalized fibroblasts. AKT1 and therelated AKT2 are activated by platelet-derived growth factor. Theactivation is rapid and specific, and it is abrogated by mutations in thepleckstrin homology domain of AKT1. It was shown that the activationoccurs through phosphatidylinositol 3-kinase. In the developing nervoussystem AKT is a critical mediator of growth factor-induced neuronalsurvival. Survival factors can suppress apoptosis in a transcriptionindependentmanner by activating the serine/threonine kinase AKT1,which then phosphorylates and inactivates components of the apoptoticmachinery. |
Immunogen | Immunogen: Peptide |
Other Names | [AKT, AKT1, PKB, PKB ALPHA, PRKBA, Protein kinase B, Proto oncogene c Akt, RAC, RAC ALPHA, RAC PK alpha] |
Gene, Accession # | [AKT1], Gene ID: 207, NCBI: BC084538, UniProt: P31749 |
Catalog # | MBS2529527 |
Price | $195, $270, $435 |
Order / More Info | AKT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |