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Antigenic Specificity | TGF-alpha |
Clone | [SPM542] |
Host Species | Mouse |
Reactive Species | human, rabbit, zebrafish. |
Isotype | IgG1, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), Immunohistology (IH) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGFalpha (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype. |
Immunogen | Immunogen: A 10-amino acid synthetic peptide (aa34-43) from human TGFalpha. Quantity and Buffer: 0.5 ml at 200ug/ml with BSA and azide |
Other Names | [EGF-like TGF; ETGF; TFGA; TGF Type 1; TGFA; Wa1; Waved 1], [TGFA; Tgfa; TFGA; TGF-alpha; ETGF] |
Gene, Accession # | [TGFA], Gene ID: 7039, NCBI: NP_001093161.1, UniProt: P01135 |
Catalog # | MBS438375 |
Price | $190, $340, $340 |
Order / More Info | TGF-alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Bebok Z; Szekeres G; Horvath G; Duda E; Nemeth P. [Creation of monoclonal antibodies against tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor alpha (TFG-alpha), their definition and possible use]. Orvosi Hetilap, 1993, 134(24):1303-7. Language: Hungarian.2. Bebok Z; Markus B; Nemeth P. Prognostic relevance of transforming growth factor alpha (TGF-alpha) and tumor necrosis factor alpha (TNF-alpha) detected in breast cancer tissues by immunohistochemistry. Breast Cancer Research and Treatment, 1994, 29(3):229-35.3. Nasim, M. M., Thomas, D. M., Alison, M. R., and Fil]ipe, M. I. Transforming growth factor a expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma - an immunohistochemical study, Histopathology. 20: 339-343, 1992. |