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Antigenic Specificity | Phospho-BCL-XL (Thr47) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-BCL-XL (Thr47) antibody detects endogenous levels of BCL-XL only when phosphorylated at Threonine 47. Description: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero-or homodimers and act as anti-or pro-apoptotic regulators that are involved in a wide variety of cellular activities.Function: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Subunit Structure: Homodimer |
Immunogen | Immunogen: A synthesized peptide derived from human BCL-XL around the phosphorylation site of Threonine 47 Subcellular Location: Mitochondrion Membrane. Nucleus Membrane. Mitochondrial Membranes and Perinuclear Envelope. Tissue Specificity: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. Predicted Cross Reactivity: Pig, Bovine |
Other Names | [Apoptosis regulator Bcl X; Apoptosis regulator Bcl-X; Apoptosis regulator BclX; B cell lymphoma 2 like; B2CL1_HUMAN; Bcl 2 like 1 protein; Bcl X; Bcl xL; BCL XL/S; Bcl xS; Bcl-2-like protein 1; Bcl2 Like 1; Bcl2 related gene; Bcl2-L-1; BCL2L; Bcl2l1; BCLX; BclXL; BclXs; DKFZp781P2092; PPP1R52; Protein phosphatase 1 regulatory subunit 52] |
Gene, Accession # | [BCL-XL], Gene ID: 598, NCBI: NP_001182.1, UniProt: Q07817 |
Catalog # | MBS9601183 |
Price | $240, $280 |
Order / More Info | Phospho-BCL-XL (Thr47) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |