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Antigenic Specificity | GRP78 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (weak), mouse, rat |
Isotype | n/a |
Format | alkaline phosphatase (AP) conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects a 78kDa protein corresponding to the molecular mass of Grp78 in SDS PAGE immunoblots. Scientific Background: GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1). GRP78 is also critical for maintenance of cell homeostas |
Immunogen | n/a |
Other Names | [BIP; Grp78; HspA5; MIF2; immunoglobulin heavy chain binding protein], [Hspa5; Hspa5; BIP; GRP78; Grp78; GRP-78; BiP] |
Gene, Accession # | Gene ID: 25617, NCBI: NP_037215.1, UniProt: P06761 |
Catalog # | MBS805019 |
Price | $405 |
Order / More Info | GRP78 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cho S., et al. (2007). Mol Cell Biol 27(1): 368-83. 2. Yang Y., et al. (1998) J Biol Chem 273: 25552-25555. 3. Luo S., et al (2006) 26 (15): 5688-97. 4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314. 5. Koomagi R., et al. (1999) Anticancer Res. 19:4333- 4336. 6. Laquerre S., et al. (1998) J. Virology 72: 4940-4949. 7. Dong D., et al. (2005) Cancer Res 65(13): 5785-91. |