p130 Cas (Tyr-762), phospho-specific Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | p130 Cas (Tyr-762), phospho-specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose and to phospho-p130 Cas (Tyr-751) peptide before affinity purification using phospho-p130 Cas (Tyr-762) peptide (without carrier). The antibody detects a 130 kDa* protein corresponding to the molecular mass of phosphorylated p130 Cas on SDS-PAGE immunoblots of pervanadate treated human A431 cells, but not in control cells. p130 Cas (Crk-associated substrate (CAS), breast cancer antiestrogen resistance 1 (BCAR1)) is a docking protein containing multiple protein-protein interaction domains. The amino-terminal SH3 domain may function as a molecular switch regulating CAS tyrosine phosphorylation, as it interacts with focal adhesion kinase (FAK) and the FAK-related kinase PY |
| Immunogen | Immunogen: Phospho-p130 Cas (Tyr-762) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 762 in the Src-binding domain of rat p130 Cas. This rat sequence is the same as Tyr-664 in human p130 Cas and Tyr-668 in mouse p130 Cas. This site is also highly conserved in Cas-L (HEF1, Nedd9). |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS472043 |
| Price | $385 |
| Order / More Info | p130 Cas (Tyr-762), phospho-specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Nakamoto, T. et al. (1996) J Biol Chem. 271 (15):8959.• Pellicena, P. & Miller, W.T. (2001) J Biol Chem. 276 (30):28190.• Kim, D.H. et al. (2003) Biochem Biophys Res Comm. 300:141.• Shin, N.-Y. et al. (2004) J Biol Chem. 279 (37):38331. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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