ATM Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | ATM |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: ATM (phospho-Ser1981) antibody detects endogenous levels of ATM only when phosphorylated at serine 1981. This gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal reces |
| Immunogen | Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S). |
| Other Names | [ATM; Serine-protein kinase ATM; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated; ATM serine/threonine kinase; Ataxia telangiectasia mutated; A-T mutated], [ATM; ATM; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1] |
| Gene, Accession # | [ATM], Gene ID: 472, NCBI: AAB65827.1 |
| Catalog # | MBS417077 |
| Price | $325 |
| Order / More Info | ATM Antibody from MYBIOSOURCE INC. |
| Product Specific References | Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305.Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252.Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119.Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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