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Antigenic Specificity | TACE |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bond metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGF-alpha, L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 810 of human TACE |
Other Names | [TACE; CD156b; Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease], [ADAM17; ADAM17; CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1; CSVP; TACE; ADAM 17] |
Gene, Accession # | [TACE], Gene ID: 6868, NCBI: NP_003174.3, UniProt: P78536 |
Catalog # | MBS840173 |
Price | $330 |
Order / More Info | TACE Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |