SLPI, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SLPI, Human |
| Clone | 31 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Immunoassay (IA), Immunoprecipitation (IP), P, Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 31 recognizes secretory leukocyte proteinase inhibitor (SLPI). SLPI was identified as an alarm reactant and expression is induced by inflammatory factors like LPS, IL1beta, TNFalpha and neutrophils elastase. SLPI is a relatively small basic antiprotease of 11.7 kDa and is a cationic non-glycosylated protein consisting of 107amino acids. SLPI has a high affinity for the neutrophil serine proteinases, elastase and cathepsin G. Orthologues of SLPI have been found in mice, rate, pigs and sheep. It consists of two highly similar WAP (?whey acid protein)/four-disulphide core domains. SLPI contain 16 cysteine residues which assemble into eight disulphide bridges (four in each WAP domain). SLPI is consti |
| Immunogen | Immunogen: SLPI purified from sputum |
| Other Names | [human seminal plasma inhibitor I (HUSI-I), cervix uterine secretion inhibitor (CUSI), bronchial inhibitor (BI), antileukoprotease (ALP) and mucous proteinase inhibitor (MPI),], [SLPI; WAP4; WFDC4; ALP; MPI] |
| Gene, Accession # | [SLPI], NCBI: CAA28187.1, UniProt: P03973 |
| Catalog # | MBS584160 |
| Price | $665 |
| Order / More Info | SLPI, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Wingens, M et al; Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J Invest Dermatol 1998, 111: 996 2. Nakao, R et al; Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte. Immunology 2003, 109: 271 3. Aarbiou, J et al. Human neuthrophil defensins and secrtory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways. Inflamm. Res 2004, 53:230-238 4. Tjabringa, S et al. Host defense effecotr molecules in mucosal secretions. FEMS immunol and med microbial 2005, 45:151 5. Bingle,L et al. WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Resp Res 2006, 7:61 6. Cheng, W et al; Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. Int J Cancer 2008, 123: 1787 7. Subramaniyam, D et al; Secretory leukocyte protease inhibitor inhibits neutrophil apoptosis. Respirology 2011, 16: 300 |
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MYBIOSOURCE INC.
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