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Antigenic Specificity | CTNNB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | beta-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates beta-catenin at Ser45. This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3beta (4-6). GSK-3beta destabilizes beta-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of beta-catenin protein levels and have been found in many tumor cell lines (8). |
Immunogen | Immunogen: A synthetic peptide of human CTNNB1 Calculated Molecular Weight: 86kDa |
Other Names | [CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; beta-catenin], [CTNNB1; CTNNB1; CTNNB; MRD19; armadillo; CTNNB] |
Gene, Accession # | [CTNNB1], Gene ID: 1499, NCBI: P35222.1, UniProt: P35222 |
Catalog # | MBS126836 |
Price | $200, $275, $430 |
Order / More Info | CTNNB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |