CTNNB1 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCTNNB1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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Descriptionbeta-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates beta-catenin at Ser45. This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3beta (4-6). GSK-3beta destabilizes beta-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of beta-catenin protein levels and have been found in many tumor cell lines (8).
ImmunogenImmunogen: A synthetic peptide of human CTNNB1 Calculated Molecular Weight: 86kDa
Other Names[CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; beta-catenin], [CTNNB1; CTNNB1; CTNNB; MRD19; armadillo; CTNNB]
Gene, Accession #[CTNNB1], Gene ID: 1499, NCBI: P35222.1, UniProt: P35222
Catalog #MBS126836
Price$200, $275, $430
Order / More InfoCTNNB1 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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