Edit |   |
---|---|
Antigenic Specificity | Bcl-2 (Phospho-Thr56) |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous human Bcl-2 only when phosphorylated at threonine 56. Bcl-2 protein suppresses apoptosis in a variety of cellular systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspase. Bcl-2 inhibits caspase acativity either by preventing release of cytochrome c from the mitochondria and/or by binding to apoptosis-activating factor (Apaf-1). The predicted molecular weight of Bcl-2 is ~26kDa. |
Immunogen | Antigen: Peptide sequence that includes phosphorylation site of threonine 56 (G-H-T(p)-P-H) derived from human Bcl-2 and conjugated to KLH. |
Other Names | [apoptosis regulator Bcl-2 alpha isoform; Apoptosis regulator Bcl-2; apoptosis regulator Bcl-2; BCL2, apoptosis regulator], [BCL2; BCL2; Bcl-2; PPP1R50] |
Gene, Accession # | [Bcl-2], Gene ID: 596, NCBI: NP_000624.2, UniProt: P10415 |
Catalog # | MBS191075 |
Price | $340 |
Order / More Info | Bcl-2 (Phospho-Thr56) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |