WWTR1 (C-term) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | WWTR1 (C-term) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This WWTR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 296-330 amino acids from the C-terminal region of human WWTR1. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activatio |
| Immunogen | n/a |
| Other Names | [WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif; WWTR1; TAZ] |
| Gene, Accession # | [WWTR1], Gene ID: 25937, NCBI: NP_001161750.1, UniProt: Q9GZV5 |
| Catalog # | MBS9202386 |
| Price | $165, $370 |
| Order / More Info | WWTR1 (C-term) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kanai F.,et al.EMBO J. 19:6778-6791(2000). Ota T.,et al.Nat. Genet. 36:40-45(2004). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Bechtel S.,et al.BMC Genomics 8:399-399(2007). Olsen J.V.,et al.Cell 127:635-648(2006). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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