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Antigenic Specificity | NOS3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Endothelial nitric-oxide synthase (eNOS) is an important enzyme in the cardiovascular system. It catalyzes the production of nitric oxide (NO), a key regulator of blood pressure, vascular remodeling, and angiogenesis (1,2). The activity of eNOS is regulated by phosphorylation at multiple sites. The two most thoroughly studied sites are the activation site Ser1177 and the inhibitory site Thr495 (3). Several protein kinases including Akt/PKB, PKA, and AMPK activate eNOS by phosphorylating Ser1177 in response to various stimuli (4,5). In contrast, bradykinin and H2O2 activate eNOS activity by promoting both Ser1177 phosphorylation and Thr495 dephosphorylation (6,7). eNOS is activated by VEGF, and this activation is associated with dephsophoryl |
Immunogen | Immunogen: A synthetic peptide of human NOS3 Calculated Molecular Weight: 133kDa |
Other Names | [eNOS; NOS3: eNOS; ECNOS], [NOS3; NOS3; eNOS; ECNOS; cNOS; eNOS; NOSIII] |
Gene, Accession # | [NOS3], Gene ID: 4846, NCBI: P29474.3, UniProt: P29474 |
Catalog # | MBS126917 |
Price | $200, $275, $430 |
Order / More Info | NOS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |