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Antigenic Specificity | Ki-67 |
Clone | polyclonal |
Host Species | Chicken |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | IgY fraction |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Specific for endogenous levels of the ~345 & 395 kDa Ki-67 isoforms. Additional bands are thought to be breakdown products of these 2 isoforms. Ki-67 is a nuclear protein that is considered to be essential for cellular proliferation since it is expressed only in active phases of the cell cycle (G1, S, G2 and mitosis) but not in resting phase G0 (Scholzen & Gerdes 2000). Ki-67 antibodies have therefore been widely used as markers of cell growth. Ki-67 has further been identified as a predicative and prognostic marker in breast, lung, cervical and other cancers (Yerushalmi et al., 2010; Folescu et al., 2018; Das et al., 2018). |
Immunogen | Immunogen Species: Human. Immunogen Information: Recombinant human ki-67 protein expressed in and purified from E Coli. |
Other Names | [proliferation marker protein Ki-67 isoform 2; Antigen KI-67; proliferation marker protein Ki-67; marker of proliferation Ki-67], [MKI67] |
Gene, Accession # | [Ki-67], Gene ID: 4288, NCBI: NP_001139438.1, UniProt: P46013 |
Catalog # | MBS500076 |
Price | $315 |
Order / More Info | Ki-67 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Scholzen T, Gerdes J. (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol. Mar;182(3):311-22. 2. Yerushalmi R, Woods R, Ravdin PM, Hayes MM, Gelmon KA (2010). Ki67 in breast cancer: prognostic and predictive potential. The Lancet. Oncology. 11 (2): 174-83. 3. Folescu R, Levai CM, Grigora? ML, Arghirescu TS, Talpos IC, Gindac CM, Zamfir CL, Poroch V, Anghel MD. (2018) Expression and significance of Ki-67 in lung cancer. Rom J Morphol Embryol.59(1):227-233. 4. Das D, Sengupta M, Basu K, Tirkey M, Datta C, Chatterjee U. (2018) Role of p16/Ki-67 Dual Immunostaining in Detection of Cervical Cancer Precursors. J Cytol. Jul-Sep;35(3):153-158. |