APPL2 - C-terminal region Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | APPL2 - C-terminal region |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 |
| Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human APPL2 |
| Other Names | [DCC-interacting protein 13-beta isoform 2; DCC-interacting protein 13-beta; DCC-interacting protein 13-beta; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2; Adapter protein containing PH domain, PTB domain and leucine zipper motif 2] |
| Gene, Accession # | [APPL2], Gene ID: 55198, NCBI: NP_001238833.1, UniProt: Q8NEU8 |
| Catalog # | MBS3221915 |
| Price | $335 |
| Order / More Info | APPL2 - C-terminal region Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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