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Antigenic Specificity | PSEN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PSEN1 antibody. Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated g-secretase activity for amyloid-b protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human PSEN1. |
Other Names | [PSEN1; AD3; FAD; PS-1; PS1; S182] |
Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: NP_000012.1, UniProt: P49768 |
Catalog # | MBS9414991 |
Price | $255 |
Order / More Info | PSEN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |